ECA’s mission is to deliver ideas and actions for an empowered, prosperous, and transformed Africa, informed by the 2030 Agenda and Agenda 2063. ECA’s dual role as a regional arm of the United Nations and a key component of the institutional landscape in Africa positions it to effectively address the continent’s development challenges support Africa’s agency and advance achievement of the 2030 Agenda and Agenda 2063 targets. ECA provides a strategic link between global guidance and policy and country-level action and provides multistakeholder and intergovernmental platforms for substantive and multidisciplinary debates on the SDGs and their implementation. ECA also offers unique integrated platforms that provide visibility to cross-border and transboundary issues, mobilizing other region-based entities such as the African Union and its regional economic communities for accelerated action to achieve the 2030 Agenda and Agenda 2063 targets. This Medium-Term Business Plan for 2024–2026 describes our strategic orientation and explains how we plan to respond to this call over the next three years. Our work aims to support the emergence of Africa as a global solutions powerhouse for energy transitions, climate action and investment for sustainable development and shared prosperity for all. ECA will deliver strategic policy options and initiatives to promote Africa’s transformation and rescue the SDGs by creating a school of thought and practice around four strategic focus areas: macroeconomic and social policy and development financing for sustainable transitions; sustainable industrialization and economic diversification through regional integration; infrastructure with a particular focus on technology, connectivity and energy; and climate resilience, green transition and food security. We will engage in these efforts in ways that strengthens Africa’s agency and leadership for transformation.